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The epidemiological data on sex differences in acetaminophen-induced liver injury in humans is inconsistent, which can be attributed to confounding factors such as variations in age, dosage, time elapsed from ingestion to hospitalization, and time from ingestion to N-acetylcysteine administration

10.1016/0140-6736(93)90882-H 116

Daly FF, Fountain JS, Murray L, et al

Clinical assessment Clinical assessment was done using modified Hemi-Melasma Area and Severity Index (HEMI-MASI) to grade the severity of melasma before and after stoppage of treatment by two blinded independent dermatologists

This is easier for larger Jupiter-like planets